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CDK9 recruitment towards the ANKRD37 as well as #links# STC2 loci can be highly activated simply by hypoxia however, significantly, is significantly reduced inside CDK8 knockdown cells ( Statistics 3H and S3B). Many mechanisms have been described to describe P-TEFb binding to be able to marketers throughout gene initial which includes hiring by DNA-binding transactivators for example MYC ( Rahl et

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